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Circular RNA AFF4 modulates osteogenic differentiation in BM-MSCs by activating SMAD1/5 pathway through miR-135a-5p/FNDC5/Irisin axis
Bone marrow-derived mesenchymal stem cells (BM-MSCs), the common progenitor cells of adipocytes and osteoblasts, have been recognized as the key mediator during bone formation. Herein, our study aim to investigate molecular mechanisms underlying circular RNA (circRNA) AFF4 (circ_AFF4)-regulated BM-M...
Autores principales: | Liu, Chao, Liu, An-Song, Zhong, Da, Wang, Cheng-Gong, Yu, Mi, Zhang, Hao-Wei, Xiao, Han, Liu, Jian-Hua, Zhang, Jian, Yin, Ke |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213698/ https://www.ncbi.nlm.nih.gov/pubmed/34145212 http://dx.doi.org/10.1038/s41419-021-03877-4 |
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