α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity

α-Synuclein aggregation is a key driver of neurodegeneration in Parkinson’s disease and related syndromes. Accordingly, obtaining a molecule that targets α-synuclein toxic assemblies with high affinity is a long-pursued objective. Here, we exploit the biophysical properties of toxic oligomers and am...

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Detalles Bibliográficos
Autores principales: Santos, Jaime, Gracia, Pablo, Navarro, Susanna, Peña-Díaz, Samuel, Pujols, Jordi, Cremades, Nunilo, Pallarès, Irantzu, Ventura, Salvador
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213730/
https://www.ncbi.nlm.nih.gov/pubmed/34145261
http://dx.doi.org/10.1038/s41467-021-24039-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213730/
https://www.ncbi.nlm.nih.gov/pubmed/34145261
http://dx.doi.org/10.1038/s41467-021-24039-2

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