Cargando…

α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity

α-Synuclein aggregation is a key driver of neurodegeneration in Parkinson’s disease and related syndromes. Accordingly, obtaining a molecule that targets α-synuclein toxic assemblies with high affinity is a long-pursued objective. Here, we exploit the biophysical properties of toxic oligomers and am...

Descripción completa

Detalles Bibliográficos
Autores principales:	Santos, Jaime, Gracia, Pablo, Navarro, Susanna, Peña-Díaz, Samuel, Pujols, Jordi, Cremades, Nunilo, Pallarès, Irantzu, Ventura, Salvador
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213730/ https://www.ncbi.nlm.nih.gov/pubmed/34145261 http://dx.doi.org/10.1038/s41467-021-24039-2

Ejemplares similares

Inhibition of α-Synuclein Aggregation and Mature Fibril Disassembling With a Minimalistic Compound, ZPDm
por: Peña-Díaz, Samuel, et al.
Publicado: (2020)

Small molecules to prevent the neurodegeneration caused by α-synuclein aggregation
por: Peña-Díaz, Samuel, et al.
Publicado: (2020)

Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in Disease
por: Gracia, Pablo, et al.
Publicado: (2020)

The Disordered C-Terminus of Yeast Hsf1 Contains a Cryptic Low-Complexity Amyloidogenic Region
por: Pujols, Jordi, et al.
Publicado: (2018)

Dissecting the contribution of Staphylococcus aureus α-phenol-soluble modulins to biofilm amyloid structure
por: Marinelli, Patrizia, et al.
Publicado: (2016)

ZPD-2, a Small Compound That Inhibits α-Synuclein Amyloid Aggregation and Its Seeded Polymerization
por: Peña-Díaz, Samuel, et al.
Publicado: (2019)

Computational prediction of protein aggregation: Advances in proteomics, conformation-specific algorithms and biotechnological applications
por: Santos, Jaime, et al.
Publicado: (2020)

aSynPEP-DB: a database of biogenic peptides for inhibiting α-synuclein aggregation
por: Pintado-Grima, Carlos, et al.
Publicado: (2023)

Identification of a nanomolar affinity α-synuclein fibril imaging probe by ultra-high throughput in silico screening
por: Ferrie, John J., et al.
Publicado: (2020)

The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains
por: Peña-Díaz, Samuel, et al.
Publicado: (2022)

Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity
por: Carija, Anita, et al.
Publicado: (2019)

High-Throughput Screening Methodology to Identify Alpha-Synuclein Aggregation Inhibitors
por: Pujols, Jordi, et al.
Publicado: (2017)

One ring is sufficient to inhibit α-synuclein aggregation
por: Peña-Díaz, Samuel, et al.
Publicado: (2021)

Inducing α-synuclein compaction: a new strategy for inhibiting α-synuclein aggregation?
por: Pinheiro, Francisca, et al.
Publicado: (2019)

Multimeric Amphipathic α‐Helical Sequences for Rapid and Efficient Intracellular Protein Transport at Nanomolar Concentrations
por: Oh, Jae Hoon, et al.
Publicado: (2018)

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells
por: Cascella, Roberta, et al.
Publicado: (2021)

Ca(2+) is a key factor in α-synuclein-induced neurotoxicity
por: Angelova, Plamena R., et al.
Publicado: (2016)

Nanomolar oligomerization and selective co-aggregation of α-synuclein pathogenic mutants revealed by single-molecule fluorescence
por: Sierecki, Emma, et al.
Publicado: (2016)

The extent of protein hydration dictates the preference for heterogeneous or homogeneous nucleation generating either parallel or antiparallel β-sheet α-synuclein aggregates
por: Camino, José D., et al.
Publicado: (2020)

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
por: Cremades, Nunilo, et al.
Publicado: (2012)

Nanoparticles With Affinity for α-Synuclein Sequester α-Synuclein to Form Toxic Aggregates in Neurons With Endolysosomal Impairment
por: Jiang, Peizhou, et al.
Publicado: (2021)

LL-37 and CsgC exemplify the crosstalk between anti-amyloid, antimicrobial, and anti-biofilm protein activities
por: Santos, Jaime, et al.
Publicado: (2022)

Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing
por: Pedersen, Jeppe T., et al.
Publicado: (2016)

Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau
por: Gracia, Pablo, et al.
Publicado: (2022)

Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions
por: Tóth, Gergely, et al.
Publicado: (2019)

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
por: Bartels, Tim, et al.
Publicado: (2011)

The Structural Combination of SIL and MODAG Scaffolds Fails to Enhance Binding to α-Synuclein but Reveals Promising Affinity to Amyloid β
por: Di Nanni, Adriana, et al.
Publicado: (2023)

Development of Small Molecules Targeting α-Synuclein Aggregation: A Promising Strategy to Treat Parkinson’s Disease
por: Peña-Díaz, Samuel, et al.
Publicado: (2023)

Cryptic amyloidogenic regions in intrinsically disordered proteins: Function and disease association
por: Santos, Jaime, et al.
Publicado: (2021)

Pulse dipolar EPR for determining nanomolar binding affinities
por: Ackermann, Katrin, et al.
Publicado: (2022)

A series of helical α-synuclein fibril polymorphs are populated in the presence of lipid vesicles
por: Meade, Richard M., et al.
Publicado: (2020)

Trifluoroethanol Modulates Amyloid Formation by the All α-Helical URN1 FF Domain
por: Marinelli, Patrizia, et al.
Publicado: (2013)

Correction: Pulse dipolar EPR for determining nanomolar binding affinities
por: Ackermann, Katrin, et al.
Publicado: (2022)

Ligand-Based Discovery of a Small Molecule as Inhibitor of α-Synuclein Amyloid Formation
por: De Luca, Laura, et al.
Publicado: (2022)

Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson’s disease
por: Vittorio, Serena, et al.
Publicado: (2020)

The Rho Termination Factor of Clostridium botulinum Contains a Prion-Like Domain with a Highly Amyloidogenic Core
por: Pallarès, Irantzu, et al.
Publicado: (2016)

Acetylated α-Tubulin and α-Synuclein: Physiological Interplay and Contribution to α-Synuclein Oligomerization
por: Calogero, Alessandra Maria, et al.
Publicado: (2023)

Transmembrane α helices
por: Mall, Sanjay, et al.
Publicado: (2002)

α-Synuclein liquid condensates fuel fibrillar α-synuclein growth
por: Piroska, Leonard, et al.
Publicado: (2023)

α-Tocopherol at Nanomolar Concentration Protects Cortical Neurons against Oxidative Stress
por: Zakharova, Irina O., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ktuh4e6q492psgg5tdbjm48qfu