Overexpression of ferroptosis defense enzyme Gpx4 retards motor neuron disease of SOD1G93A mice

Degeneration and death of motor neurons in Amyotrophic Lateral Sclerosis (ALS) are associated with increased lipid peroxidation. Lipid peroxidation is the driver of ferroptosis, an iron-dependent oxidative mode of cell death. However, the importance of ferroptosis in motor neuron degeneration of ALS...

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Detalles Bibliográficos
Autores principales: Chen, Liuji, Na, Ren, Danae McLane, Kirsten, Thompson, Cody Sylvester, Gao, Ju, Wang, Xinglong, Ran, Qitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213805/
https://www.ncbi.nlm.nih.gov/pubmed/34145375
http://dx.doi.org/10.1038/s41598-021-92369-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213805/
https://www.ncbi.nlm.nih.gov/pubmed/34145375
http://dx.doi.org/10.1038/s41598-021-92369-8

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