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Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
C. difficile is a major cause of antibiotic-associated gastrointestinal infections. Two C. difficile exotoxins (TcdA and TcdB) are major virulence factors associated with these infections, and chondroitin sulfate proteoglycan 4 (CSPG4) is a potential receptor for TcdB, but its pathophysiological rel...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213806/ https://www.ncbi.nlm.nih.gov/pubmed/34145250 http://dx.doi.org/10.1038/s41467-021-23878-3 |