Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo

The novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the recent global pandemic. The nuclear export protein (XPO1) has a direct role in the export of SARS-CoV proteins including ORF3b, ORF9b, and nucleocapsid. Inh...

Descripción completa

Detalles Bibliográficos
Autores principales: Kashyap, Trinayan, Murray, Jackelyn, Walker, Christopher J., Chang, Hua, Tamir, Sharon, Hou, Bing, Shacham, Sharon, Kauffman, Michael G., Tripp, Ralph A., Landesman, Yosef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213878/
https://www.ncbi.nlm.nih.gov/pubmed/34157321
http://dx.doi.org/10.1016/j.antiviral.2021.105115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213878/
https://www.ncbi.nlm.nih.gov/pubmed/34157321
http://dx.doi.org/10.1016/j.antiviral.2021.105115

Ejemplares similares