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Enabling Photoactivated Cross-Linking Mass Spectrometric Analysis of Protein Complexes by Novel MS-Cleavable Cross-Linkers

Cross-linking mass spectrometry (XL-MS) is a powerful tool for studying protein–protein interactions and elucidating architectures of protein complexes. While residue-specific XL-MS studies have been very successful, accessibility of interaction regions nontargetable by specific chemistries remain d...

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Detalles Bibliográficos
Autores principales: Gutierrez, Craig, Salituro, Leah J., Yu, Clinton, Wang, Xiaorong, DePeter, Sadie F., Rychnovsky, Scott D., Huang, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214149/
https://www.ncbi.nlm.nih.gov/pubmed/33915260
http://dx.doi.org/10.1016/j.mcpro.2021.100084