Doxorubicin Delivered via ApoE-Directed Reduction-Sensitive Polymersomes Potently Inhibit Orthotopic Human Glioblastoma Xenografts in Nude Mice

PURPOSE: Glioblastoma multiforme (GBM) poorly responds to chemotherapy owing to the existence of blood-brain barriers (BBB). It has been a long desire to develop BBB-permeable vehicles to facilitate drug targeting to GBM. METHOD AND RESULTS: Here, we report that doxorubicin hydrochloride loaded in A...

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Detalles Bibliográficos
Autores principales: Ouyang, Jia, Jiang, Yu, Deng, Chao, Zhong, Zhiyuan, Lan, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214541/
https://www.ncbi.nlm.nih.gov/pubmed/34163162
http://dx.doi.org/10.2147/IJN.S314895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214541/
https://www.ncbi.nlm.nih.gov/pubmed/34163162
http://dx.doi.org/10.2147/IJN.S314895

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