ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy

TANK-binding kinase 1 (TBK1) is a multifunctional kinase with an essential role in mitophagy, the selective clearance of damaged mitochondria. More than 90 distinct mutations in TBK1 are linked to amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia, including missense mutations that dis...

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Detalles Bibliográficos
Autores principales: Harding, Olivia, Evans, Chantell S., Ye, Junqiang, Cheung, Jonah, Maniatis, Tom, Holzbaur, Erika L. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214690/
https://www.ncbi.nlm.nih.gov/pubmed/34099552
http://dx.doi.org/10.1073/pnas.2025053118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214690/
https://www.ncbi.nlm.nih.gov/pubmed/34099552
http://dx.doi.org/10.1073/pnas.2025053118

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