Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state

Hypertrophic cardiomyopathy (HCM) is the most common inherited form of heart disease, associated with over 1,000 mutations, many in β-cardiac myosin (MYH7). Molecular studies of myosin with different HCM mutations have revealed a diversity of effects on ATPase and load-sensitive rate of detachment f...

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Detalles Bibliográficos
Autores principales: Vander Roest, Alison Schroer, Liu, Chao, Morck, Makenna M., Kooiker, Kristina Bezold, Jung, Gwanghyun, Song, Dan, Dawood, Aminah, Jhingran, Arnav, Pardon, Gaspard, Ranjbarvaziri, Sara, Fajardo, Giovanni, Zhao, Mingming, Campbell, Kenneth S., Pruitt, Beth L., Spudich, James A., Ruppel, Kathleen M., Bernstein, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214707/
https://www.ncbi.nlm.nih.gov/pubmed/34117120
http://dx.doi.org/10.1073/pnas.2025030118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214707/
https://www.ncbi.nlm.nih.gov/pubmed/34117120
http://dx.doi.org/10.1073/pnas.2025030118

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