Development of a physiologically relevant and easily scalable LUHMES cell-based model of G2019S LRRK2-driven Parkinson's disease

Parkinson's disease (PD) is a fatal neurodegenerative disorder that is primarily caused by the degeneration and loss of dopaminergic neurons of the substantia nigra in the ventral midbrain. Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of late-onset PD iden...

Descripción completa

Detalles Bibliográficos
Autores principales: Calamini, Barbara, Geyer, Nathalie, Huss-Braun, Nathalie, Bernhardt, Annie, Harsany, Véronique, Rival, Pierrick, Cindhuchao, May, Hoffmann, Dietmar, Gratzer, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214734/
https://www.ncbi.nlm.nih.gov/pubmed/34114604
http://dx.doi.org/10.1242/dmm.048017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214734/
https://www.ncbi.nlm.nih.gov/pubmed/34114604
http://dx.doi.org/10.1242/dmm.048017

Ejemplares similares