Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2α/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via Reducing the Reactive Oxygen Species and Apoptosis of Nucleus Pulposus Cells

Excessive reactive oxygen species (ROS) and apoptosis in nucleus pulposus (NP) cells accelerate the process of intervertebral disc degeneration (IDD). Here, we integrated pathological samples and in vitro and in vivo framework to investigate the impact of phosphorylation of eukaryotic initiation fac...

Descripción completa

Detalles Bibliográficos
Autores principales: Bao, Junping, Qian, Zhanyang, Liu, Lei, Hong, Xin, Che, Hui, Wu, Xiaotao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215438/
https://www.ncbi.nlm.nih.gov/pubmed/34164397
http://dx.doi.org/10.3389/fcell.2021.675486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215438/
https://www.ncbi.nlm.nih.gov/pubmed/34164397
http://dx.doi.org/10.3389/fcell.2021.675486

Ejemplares similares