CUL5–ASB6 Complex Promotes p62/SQSTM1 Ubiquitination and Degradation to Regulate Cell Proliferation and Autophagy

p62/SQSTM1 (sequestosome-1) is a key protein involved in multiple cellular bioprocesses including autophagy, nutrient sensing, cell growth, cell death, and survival. Therefore, it is implicated in human diseases such as obesity and cancer. Here, we show that the CUL5–ASB6 complex is a ubiquitin E3 l...

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Detalles Bibliográficos
Autores principales: Gong, Liyan, Wang, Kaihua, Wang, Mengcheng, Hu, Ronggui, Li, Huaguang, Gao, Daming, Lin, Moubin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215545/
https://www.ncbi.nlm.nih.gov/pubmed/34164402
http://dx.doi.org/10.3389/fcell.2021.684885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215545/
https://www.ncbi.nlm.nih.gov/pubmed/34164402
http://dx.doi.org/10.3389/fcell.2021.684885

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