Sizing, stabilising, and cloning repeat-expansions for gene targeting constructs

Aberrant microsatellite repeat-expansions at specific loci within the human genome cause several distinct, heritable, and predominantly neurological, disorders. Creating models for these diseases poses a challenge, due to the instability of such repeats in bacterial vectors, especially with large re...

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Detalles Bibliográficos
Autores principales: Nair, Remya R., Tibbit, Charlotte, Thompson, David, McLeod, Ross, Nakhuda, Asif, Simon, Michelle M., Baloh, Robert H., Fisher, Elizabeth M.C., Isaacs, Adrian M., Cunningham, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215685/
https://www.ncbi.nlm.nih.gov/pubmed/32721467
http://dx.doi.org/10.1016/j.ymeth.2020.07.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215685/
https://www.ncbi.nlm.nih.gov/pubmed/32721467
http://dx.doi.org/10.1016/j.ymeth.2020.07.007

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