Solving the Problem of Assessing Synergy and Antagonism for Non-Traditional Dosing Curve Compounds Using the DE/ZI Method: Application to Nrf2 Activators

Multi-drug combination therapy carries significant promise for pharmacological intervention, primarily better efficacy with less toxicity and fewer side effects. However, the field lacks methodology to assess synergistic or antagonistic interactions for drugs with non-traditional dose response curve...

Descripción completa

Detalles Bibliográficos
Autores principales: Repash, Elizabeth M., Pensabene, Kaitlin M., Palenchar, Peter M., Eggler, Aimee L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215699/
https://www.ncbi.nlm.nih.gov/pubmed/34163365
http://dx.doi.org/10.3389/fphar.2021.686201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215699/
https://www.ncbi.nlm.nih.gov/pubmed/34163365
http://dx.doi.org/10.3389/fphar.2021.686201

Ejemplares similares