Cargando…

Differential seeding and propagating efficiency of α-synuclein strains generated in different conditions

BACKGROUND: Accumulation of alpha-synuclein (α-syn) is a main pathological hallmark of Parkinson’s and related diseases, which are collectively known as synucleinopathies. Growing evidence has supported that the same protein can induce remarkably distinct pathological progresses and disease phenotyp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Di, Guo, Jian-Jun, Su, Ji-Hui, Svanbergsson, Alexander, Yuan, Lin, Haikal, Caroline, Li, Wen, Gouras, Gunnar, Li, Jia-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215826/ https://www.ncbi.nlm.nih.gov/pubmed/34148543 http://dx.doi.org/10.1186/s40035-021-00242-5

Ejemplares similares

FRET-Based Screening Identifies p38 MAPK and PKC Inhibition as Targets for Prevention of Seeded α-Synuclein Aggregation
por: Svanbergsson, Alexander, et al.
Publicado: (2021)

Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation
por: Torres-Garcia, Laura, et al.
Publicado: (2022)

Propagative α-synuclein seeds as serum biomarkers for synucleinopathies
por: Okuzumi, Ayami, et al.
Publicado: (2023)

The Bacterial Amyloids Phenol Soluble Modulins from Staphylococcus aureus Catalyze Alpha-Synuclein Aggregation
por: Haikal, Caroline, et al.
Publicado: (2021)

Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network
por: Gribaudo, Simona, et al.
Publicado: (2019)

Differentially targeted seeding reveals unique pathological alpha-synuclein propagation patterns
por: Rahayel, Shady, et al.
Publicado: (2021)

Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation
por: Oueslati, Abid, et al.
Publicado: (2014)

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
por: Tran, Hien T., et al.
Publicado: (2014)

Propagation of pathological α-synuclein in marmoset brain
por: Shimozawa, Aki, et al.
Publicado: (2017)

Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy
por: Wu, Jia-Zhen, et al.
Publicado: (2019)

Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein
por: Frieg, Benedikt, et al.
Publicado: (2022)

Modeling α-Synuclein Propagation with Preformed Fibril Injections
por: Chung, Hyun Kyung, et al.
Publicado: (2019)

Modeling α-Synuclein Propagation with Preformed Fibril Injections
por: Chung, Hyun Kyung, et al.
Publicado: (2020)

Initiation and propagation of α-synuclein aggregation in the nervous system
por: Hijaz, Baraa A., et al.
Publicado: (2020)

Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs
por: Shrivastava, Amulya Nidhi, et al.
Publicado: (2020)

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb
por: Rey, Nolwen L., et al.
Publicado: (2019)

Effect of L-DOPA/Benserazide on Propagation of Pathological α-Synuclein
por: Shimozawa, Aki, et al.
Publicado: (2019)

Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury
por: Ulusoy, Ayse, et al.
Publicado: (2015)

Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system
por: Lopes, Douglas M., et al.
Publicado: (2022)

Statins suppress cell-to-cell propagation of α-synuclein by lowering cholesterol
por: Min, Joo-Ok, et al.
Publicado: (2023)

α-synuclein strains that cause distinct pathologies differentially inhibit proteasome
por: Suzuki, Genjiro, et al.
Publicado: (2020)

Differential cross-seeding properties of tau and α-synuclein in mouse models of tauopathy and synucleinopathy
por: Williams, Tosha, et al.
Publicado: (2020)

Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril
por: Kim, Changyoun, et al.
Publicado: (2016)

Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice
por: Koller, Emily J., et al.
Publicado: (2017)

Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein
por: Reimer, Lasse, et al.
Publicado: (2022)

Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity
por: Yang, Xue, et al.
Publicado: (2019)

Determinants of seeding and spreading of α-synuclein pathology in the brain
por: Henrich, Martin T., et al.
Publicado: (2020)

Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy
por: Spencer, Brian, et al.
Publicado: (2017)

TNF-α promotes α-synuclein propagation through stimulation of senescence-associated lysosomal exocytosis
por: Bae, Eun-Jin, et al.
Publicado: (2022)

Single cell imaging and quantification of TDP-43 and α-synuclein intercellular propagation
por: Peled, Sivan, et al.
Publicado: (2017)

Chicago sky blue 6B inhibits α-synuclein aggregation and propagation
por: Min, Joo-Ok, et al.
Publicado: (2022)

Brain region-specific microglial and astrocytic activation in response to systemic lipopolysaccharides exposure
por: Brandi, Edoardo, et al.
Publicado: (2022)

Neurons with Cat’s Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions
por: De Giorgi, Francesca, et al.
Publicado: (2022)

Selective neurodegeneration generated by intravenous α‐synuclein pre‐formed fibril administration is not associated with endogenous α‐synuclein levels in the rat brain
por: Kuan, Wei‐Li, et al.
Publicado: (2022)

Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity
por: Gupta, Vijay, et al.
Publicado: (2020)

α-Synuclein-derived lipoparticles in the study of α-Synuclein amyloid fibril formation
por: Falke, Marcel, et al.
Publicado: (2019)

LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation
por: Bae, Eun-Jin, et al.
Publicado: (2018)

Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology
por: Ngolab, Jennifer, et al.
Publicado: (2017)

Conformation-specific Antibodies Targeting Aggregated Forms of α-synuclein Block the Propagation of Synucleinopathy
por: Choi, Minsun, et al.
Publicado: (2022)

α-Synuclein propagation leads to synaptic abnormalities in the cortex through microglial synapse phagocytosis
por: Pérez-Acuña, Dayana, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_vra3dc5j7rpsro9cl160fcm05l