Structural basis of Staphylococcus aureus Cas9 inhibition by AcrIIA14

Bacteriophages have evolved a range of anti-CRISPR proteins (Acrs) to escape the adaptive immune system of prokaryotes, therefore Acrs can be used as switches to regulate gene editing. Herein, we report the crystal structure of a quaternary complex of AcrIIA14 bound SauCas9–sgRNA–dsDNA at 2.22 Å res...

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Detalles Bibliográficos
Autores principales: Liu, Hongnan, Zhu, Yuwei, Lu, Zebin, Huang, Zhiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216286/
https://www.ncbi.nlm.nih.gov/pubmed/34107040
http://dx.doi.org/10.1093/nar/gkab487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216286/
https://www.ncbi.nlm.nih.gov/pubmed/34107040
http://dx.doi.org/10.1093/nar/gkab487

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