Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4(+) T Cells in Type 1 Diabetes

In Type 1 Diabetes (T1D), CD4(+) T cells initiate autoimmune attack of pancreatic islet β cells. Importantly, bioenergetic programs dictate T cell function, with specific pathways required for progression through the T cell lifecycle. During activation, CD4(+) T cells undergo metabolic reprogramming...

Descripción completa

Detalles Bibliográficos
Autores principales: Martins, Christina P., New, Lee A., O’Connor, Erin C., Previte, Dana M., Cargill, Kasey R., Tse, Isabelle L., Sims- Lucas, Sunder, Piganelli, Jon D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216385/
https://www.ncbi.nlm.nih.gov/pubmed/34163475
http://dx.doi.org/10.3389/fimmu.2021.669456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216385/
https://www.ncbi.nlm.nih.gov/pubmed/34163475
http://dx.doi.org/10.3389/fimmu.2021.669456

Ejemplares similares