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Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4(+) T Cells in Type 1 Diabetes
In Type 1 Diabetes (T1D), CD4(+) T cells initiate autoimmune attack of pancreatic islet β cells. Importantly, bioenergetic programs dictate T cell function, with specific pathways required for progression through the T cell lifecycle. During activation, CD4(+) T cells undergo metabolic reprogramming...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216385/ https://www.ncbi.nlm.nih.gov/pubmed/34163475 http://dx.doi.org/10.3389/fimmu.2021.669456 |