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Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4(+) T Cells in Type 1 Diabetes

In Type 1 Diabetes (T1D), CD4(+) T cells initiate autoimmune attack of pancreatic islet β cells. Importantly, bioenergetic programs dictate T cell function, with specific pathways required for progression through the T cell lifecycle. During activation, CD4(+) T cells undergo metabolic reprogramming...

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Detalles Bibliográficos
Autores principales:	Martins, Christina P., New, Lee A., O’Connor, Erin C., Previte, Dana M., Cargill, Kasey R., Tse, Isabelle L., Sims- Lucas, Sunder, Piganelli, Jon D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216385/ https://www.ncbi.nlm.nih.gov/pubmed/34163475 http://dx.doi.org/10.3389/fimmu.2021.669456

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