Molecular docking and statistical optimization of taurocholate-stabilized galactose anchored bilosomes for the enhancement of sofosbuvir absorption and hepatic relative targeting efficiency

The work aimed to improve both absorption and hepatic availability of sofosbuvir. Bilosomes and galactose-anchored bilosomes were investigated as potential nanocarriers for this purpose. Sofosbuvir is a class III drug with high solubility and low permeability. Thus, the drug entrapment into lipid-ba...

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Detalles Bibliográficos
Autores principales: Joseph Naguib, Marianne, Moustafa Kamel, Amira, Thabet Negmeldin, Ahmed, Elshafeey, Ahmed Hassen, Elsayed, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216436/
https://www.ncbi.nlm.nih.gov/pubmed/32611266
http://dx.doi.org/10.1080/10717544.2020.1787557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216436/
https://www.ncbi.nlm.nih.gov/pubmed/32611266
http://dx.doi.org/10.1080/10717544.2020.1787557

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