Cargando…

Molecular docking and statistical optimization of taurocholate-stabilized galactose anchored bilosomes for the enhancement of sofosbuvir absorption and hepatic relative targeting efficiency

The work aimed to improve both absorption and hepatic availability of sofosbuvir. Bilosomes and galactose-anchored bilosomes were investigated as potential nanocarriers for this purpose. Sofosbuvir is a class III drug with high solubility and low permeability. Thus, the drug entrapment into lipid-ba...

Descripción completa

Detalles Bibliográficos
Autores principales:	Joseph Naguib, Marianne, Moustafa Kamel, Amira, Thabet Negmeldin, Ahmed, Elshafeey, Ahmed Hassen, Elsayed, Ibrahim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216436/ https://www.ncbi.nlm.nih.gov/pubmed/32611266 http://dx.doi.org/10.1080/10717544.2020.1787557

Ejemplares similares

Pitavastatin-loaded bilosomes for oral treatment of hepatocellular carcinoma: a repurposing approach
por: Kharouba, Maged, et al.
Publicado: (2022)

Nanosizing of a poorly soluble drug: technique optimization, factorial analysis, and pharmacokinetic study in healthy human volunteers
por: Elsayed, Ibrahim, et al.
Publicado: (2014)

Brain Targeting of Duloxetine HCL via Intranasal Delivery of Loaded Cubosomal Gel: In vitro Characterization, ex vivo Permeation, and in vivo Biodistribution Studies
por: Elsenosy, Fatma Mohamed, et al.
Publicado: (2020)

Galactose supramolecular docking orchestrates macrophage phenotype
por: Zhang, Nu, et al.
Publicado: (2020)

Improving intestinal absorption and oral bioavailability of curcumin via taurocholic acid-modified nanostructured lipid carriers
por: Tian, Cihui, et al.
Publicado: (2017)

Evaluation of Metformin Hydrochloride Tailoring Bilosomes as an Effective Transdermal Nanocarrier
por: Salem, Heba F, et al.
Publicado: (2022)

Sodium Taurocholate Micelles in Fluorometrix Analysis
por: McGown, Linda B., et al.
Publicado: (1988)

Novel Surface-Modified Bilosomes as Functional and Biocompatible Nanocarriers of Hybrid Compounds
por: Waglewska, Ewelina, et al.
Publicado: (2020)

Bilosomes as Nanoplatform for Oral Delivery and Modulated In Vivo Antimicrobial Activity of Lycopene
por: Binsuwaidan, Reem, et al.
Publicado: (2022)

Novel Siprulina platensis Bilosomes for Combating UVB Induced Skin Damage
por: Zewail, Mariam, et al.
Publicado: (2022)

Formulation and Development of Oral Fast-Dissolving Films Loaded with Nanosuspension to Augment Paroxetine Bioavailability: In Vitro Characterization, Ex Vivo Permeation, and Pharmacokinetic Evaluation in Healthy Human Volunteers
por: Elshafeey, Ahmed Hassen, et al.
Publicado: (2021)

A novel oral medicated jelly for enhancement of etilefrine hydrochloride bioavailability: In vitro characterization and pharmacokinetic evaluation in healthy human volunteers
por: Hassen Elshafeey, Ahmed, et al.
Publicado: (2022)

Bilosomes as Promising Nanovesicular Carriers for Improved Transdermal Delivery: Construction, in vitro Optimization, ex vivo Permeation and in vivo Evaluation
por: Ahmed, Sadek, et al.
Publicado: (2020)

Enhanced Bilosomal Properties Resulted in Optimum Pharmacological Effects by Increased Acidification Pathways
por: Mooranian, Armin, et al.
Publicado: (2021)

Bioactive Apigenin loaded oral nano bilosomes: Formulation optimization to preclinical assessment
por: Zafar, Ameeduzzafar, et al.
Publicado: (2021)

Formulation of Chitosan-Coated Apigenin Bilosomes: In Vitro Characterization, Antimicrobial and Cytotoxicity Assessment
por: Imam, Syed Sarim, et al.
Publicado: (2022)

Formulation and Evaluation of Moxifloxacin Loaded Bilosomes In-Situ Gel: Optimization to Antibacterial Evaluation
por: Zafar, Ameeduzzafar, et al.
Publicado: (2022)

Bilosomes as Nanocarriers for the Drug and Vaccine Delivery against Gastrointestinal Infections: Opportunities and Challenges
por: Zarenezhad, Elham, et al.
Publicado: (2023)

The ameliorating role of sofosbuvir and daclatasvir on thioacetamide-induced kidney injury in adult albino rats
por: Moustafa, Ahmed H., et al.
Publicado: (2023)

Piceatannol-Loaded Bilosome-Stabilized Zein Protein Exhibits Enhanced Cytostatic and Apoptotic Activities in Lung Cancer Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2021)

The Tragedy of Alzheimer’s Disease: Towards Better Management via Resveratrol-Loaded Oral Bilosomes
por: Abbas, Haidy, et al.
Publicado: (2021)

Development and evaluation of luteolin loaded pegylated bilosome: optimization, in vitro characterization, and cytotoxicity study
por: Zafar, Ameeduzzafar, et al.
Publicado: (2021)

Vardenafil-Loaded Bilosomal Mucoadhesive Sponge for Buccal Delivery: Optimization, Characterization, and In Vivo Evaluation
por: Aldawsari, Mohammed F., et al.
Publicado: (2022)

Formulation and optimization of duloxetine hydrochloride buccal films: in vitro and in vivo evaluation
por: El Sharawy, Amr Mostafa, et al.
Publicado: (2017)

Assessment of auditory functions in chronic hepatitis C patients treated by sofosbuvir
por: Ismail, Elshahat Ibrahem, et al.
Publicado: (2018)

Tripling the Bioavailability of Rosuvastatin Calcium Through Development and Optimization of an In-Situ Forming Nanovesicular System
por: Elsayed, Ibrahim, et al.
Publicado: (2019)

Transdermal agomelatine microemulsion gel: pyramidal screening, statistical optimization and in vivo bioavailability
por: Said, Mayada, et al.
Publicado: (2017)

Recombinant Baculovirus Associated with Bilosomes as an Oral Vaccine Candidate against HEV71 Infection in Mice
por: Premanand, Balraj, et al.
Publicado: (2013)

Hyaluronic acid-functionalized bilosomes for targeted delivery of tripterine to inflamed area with enhancive therapy on arthritis
por: Yang, Hailing, et al.
Publicado: (2019)

Oral Delivery of Psoralidin by Mucoadhesive Surface-Modified Bilosomes Showed Boosted Apoptotic and Necrotic Effects against Breast and Lung Cancer Cells
por: Youness, Rana Ahmed, et al.
Publicado: (2023)

VOLUME CHANGES IN HEMOLYTIC SYSTEMS CONTAINING RESORCINOL, TAUROCHOLATE, AND SAPONIN
por: Ponder, Eric
Publicado: (1948)

HEMOLYSIS BY SAPONIN AND SODIUM TAUROCHOLATE, WITH SPECIAL REFERENCE TO THE SERIES OF RYVOSH
por: Yeager, J. Franklin
Publicado: (1928)

Sodium(+)/taurocholate cotransporting polypeptide as target therapy for liver fibrosis
por: Salhab, Ahmad, et al.
Publicado: (2022)

Implementing Spanlastics for Improving the Ocular Delivery of Clotrimazole: In vitro Characterization, Ex vivo Permeability, Microbiological Assessment and In vivo Safety Study
por: Abdelbari, Manar Adel, et al.
Publicado: (2021)

Sofosbuvir and daclatasvir
por: Hessel, Marleen H. M., et al.
Publicado: (2016)

Facilitated permeation of insulin across TR146 cells by cholic acid derivatives-modified elastic bilosomes
por: Bashyal, Santosh, et al.
Publicado: (2018)

Intranasal Zolmitriptan-Loaded Bilosomes with Extended Nasal Mucociliary Transit Time for Direct Nose to Brain Delivery
por: El Taweel, Mai M., et al.
Publicado: (2021)

Development of an Icariin-Loaded Bilosome-Melittin Formulation with Improved Anticancer Activity against Cancerous Pancreatic Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2021)

Budesonide-Loaded Bilosomes as a Targeted Delivery Therapeutic Approach Against Acute Lung Injury in Rats
por: Salem, Heba F., et al.
Publicado: (2023)

Use of Novasomes as a Vesicular Carrier for Improving the Topical Delivery of Terconazole: In Vitro Characterization, In Vivo Assessment and Exploratory Clinical Experimentation
por: Mosallam, Shaimaa, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_25g04hdpvh7fg4rv6as09es4vk