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The leucine-NH4(+) uptake regulator Any1 limits growth as part of a general amino acid control response to loss of La protein by fission yeast
The sla1(+) gene of Schizosachharoymces pombe encodes La protein which promotes proper processing of precursor-tRNAs. Deletion of sla1 (sla1Δ) leads to disrupted tRNA processing and sensitivity to target of rapamycin (TOR) inhibition. Consistent with this, media containing NH4(+) inhibits leucine up...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216550/ https://www.ncbi.nlm.nih.gov/pubmed/34153074 http://dx.doi.org/10.1371/journal.pone.0253494 |