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Cortical signatures of precision grip force control in children, adolescents, and adults

Human dexterous motor control improves from childhood to adulthood, but little is known about the changes in cortico-cortical communication that support such ontogenetic refinement of motor skills. To investigate age-related differences in connectivity between cortical regions involved in dexterous...

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Autores principales: Beck, Mikkel Malling, Spedden, Meaghan Elizabeth, Dietz, Martin Jensen, Karabanov, Anke Ninija, Christensen, Mark Schram, Lundbye-Jensen, Jesper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216716/
https://www.ncbi.nlm.nih.gov/pubmed/34121656
http://dx.doi.org/10.7554/eLife.61018
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author Beck, Mikkel Malling
Spedden, Meaghan Elizabeth
Dietz, Martin Jensen
Karabanov, Anke Ninija
Christensen, Mark Schram
Lundbye-Jensen, Jesper
author_facet Beck, Mikkel Malling
Spedden, Meaghan Elizabeth
Dietz, Martin Jensen
Karabanov, Anke Ninija
Christensen, Mark Schram
Lundbye-Jensen, Jesper
author_sort Beck, Mikkel Malling
collection PubMed
description Human dexterous motor control improves from childhood to adulthood, but little is known about the changes in cortico-cortical communication that support such ontogenetic refinement of motor skills. To investigate age-related differences in connectivity between cortical regions involved in dexterous control, we analyzed electroencephalographic data from 88 individuals (range 8-30 years) performing a visually guided precision grip task using dynamic causal modelling and parametric empirical Bayes. Our results demonstrate that bidirectional coupling in a canonical ‘grasping network’ is associated with precision grip performance across age groups. We further demonstrate greater backward coupling from higher-order to lower-order sensorimotor regions from late adolescence in addition to differential associations between connectivity strength in a premotor-prefrontal network and motor performance for different age groups. We interpret these findings as reflecting greater use of top-down and executive control processes with development. These results expand our understanding of the cortical mechanisms that support dexterous abilities through development.
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spelling pubmed-82167162021-06-23 Cortical signatures of precision grip force control in children, adolescents, and adults Beck, Mikkel Malling Spedden, Meaghan Elizabeth Dietz, Martin Jensen Karabanov, Anke Ninija Christensen, Mark Schram Lundbye-Jensen, Jesper eLife Neuroscience Human dexterous motor control improves from childhood to adulthood, but little is known about the changes in cortico-cortical communication that support such ontogenetic refinement of motor skills. To investigate age-related differences in connectivity between cortical regions involved in dexterous control, we analyzed electroencephalographic data from 88 individuals (range 8-30 years) performing a visually guided precision grip task using dynamic causal modelling and parametric empirical Bayes. Our results demonstrate that bidirectional coupling in a canonical ‘grasping network’ is associated with precision grip performance across age groups. We further demonstrate greater backward coupling from higher-order to lower-order sensorimotor regions from late adolescence in addition to differential associations between connectivity strength in a premotor-prefrontal network and motor performance for different age groups. We interpret these findings as reflecting greater use of top-down and executive control processes with development. These results expand our understanding of the cortical mechanisms that support dexterous abilities through development. eLife Sciences Publications, Ltd 2021-06-14 /pmc/articles/PMC8216716/ /pubmed/34121656 http://dx.doi.org/10.7554/eLife.61018 Text en © 2021, Beck et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Beck, Mikkel Malling
Spedden, Meaghan Elizabeth
Dietz, Martin Jensen
Karabanov, Anke Ninija
Christensen, Mark Schram
Lundbye-Jensen, Jesper
Cortical signatures of precision grip force control in children, adolescents, and adults
title Cortical signatures of precision grip force control in children, adolescents, and adults
title_full Cortical signatures of precision grip force control in children, adolescents, and adults
title_fullStr Cortical signatures of precision grip force control in children, adolescents, and adults
title_full_unstemmed Cortical signatures of precision grip force control in children, adolescents, and adults
title_short Cortical signatures of precision grip force control in children, adolescents, and adults
title_sort cortical signatures of precision grip force control in children, adolescents, and adults
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216716/
https://www.ncbi.nlm.nih.gov/pubmed/34121656
http://dx.doi.org/10.7554/eLife.61018
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