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Cortical signatures of precision grip force control in children, adolescents, and adults
Human dexterous motor control improves from childhood to adulthood, but little is known about the changes in cortico-cortical communication that support such ontogenetic refinement of motor skills. To investigate age-related differences in connectivity between cortical regions involved in dexterous...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216716/ https://www.ncbi.nlm.nih.gov/pubmed/34121656 http://dx.doi.org/10.7554/eLife.61018 |
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author | Beck, Mikkel Malling Spedden, Meaghan Elizabeth Dietz, Martin Jensen Karabanov, Anke Ninija Christensen, Mark Schram Lundbye-Jensen, Jesper |
author_facet | Beck, Mikkel Malling Spedden, Meaghan Elizabeth Dietz, Martin Jensen Karabanov, Anke Ninija Christensen, Mark Schram Lundbye-Jensen, Jesper |
author_sort | Beck, Mikkel Malling |
collection | PubMed |
description | Human dexterous motor control improves from childhood to adulthood, but little is known about the changes in cortico-cortical communication that support such ontogenetic refinement of motor skills. To investigate age-related differences in connectivity between cortical regions involved in dexterous control, we analyzed electroencephalographic data from 88 individuals (range 8-30 years) performing a visually guided precision grip task using dynamic causal modelling and parametric empirical Bayes. Our results demonstrate that bidirectional coupling in a canonical ‘grasping network’ is associated with precision grip performance across age groups. We further demonstrate greater backward coupling from higher-order to lower-order sensorimotor regions from late adolescence in addition to differential associations between connectivity strength in a premotor-prefrontal network and motor performance for different age groups. We interpret these findings as reflecting greater use of top-down and executive control processes with development. These results expand our understanding of the cortical mechanisms that support dexterous abilities through development. |
format | Online Article Text |
id | pubmed-8216716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-82167162021-06-23 Cortical signatures of precision grip force control in children, adolescents, and adults Beck, Mikkel Malling Spedden, Meaghan Elizabeth Dietz, Martin Jensen Karabanov, Anke Ninija Christensen, Mark Schram Lundbye-Jensen, Jesper eLife Neuroscience Human dexterous motor control improves from childhood to adulthood, but little is known about the changes in cortico-cortical communication that support such ontogenetic refinement of motor skills. To investigate age-related differences in connectivity between cortical regions involved in dexterous control, we analyzed electroencephalographic data from 88 individuals (range 8-30 years) performing a visually guided precision grip task using dynamic causal modelling and parametric empirical Bayes. Our results demonstrate that bidirectional coupling in a canonical ‘grasping network’ is associated with precision grip performance across age groups. We further demonstrate greater backward coupling from higher-order to lower-order sensorimotor regions from late adolescence in addition to differential associations between connectivity strength in a premotor-prefrontal network and motor performance for different age groups. We interpret these findings as reflecting greater use of top-down and executive control processes with development. These results expand our understanding of the cortical mechanisms that support dexterous abilities through development. eLife Sciences Publications, Ltd 2021-06-14 /pmc/articles/PMC8216716/ /pubmed/34121656 http://dx.doi.org/10.7554/eLife.61018 Text en © 2021, Beck et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Beck, Mikkel Malling Spedden, Meaghan Elizabeth Dietz, Martin Jensen Karabanov, Anke Ninija Christensen, Mark Schram Lundbye-Jensen, Jesper Cortical signatures of precision grip force control in children, adolescents, and adults |
title | Cortical signatures of precision grip force control in children, adolescents, and adults |
title_full | Cortical signatures of precision grip force control in children, adolescents, and adults |
title_fullStr | Cortical signatures of precision grip force control in children, adolescents, and adults |
title_full_unstemmed | Cortical signatures of precision grip force control in children, adolescents, and adults |
title_short | Cortical signatures of precision grip force control in children, adolescents, and adults |
title_sort | cortical signatures of precision grip force control in children, adolescents, and adults |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216716/ https://www.ncbi.nlm.nih.gov/pubmed/34121656 http://dx.doi.org/10.7554/eLife.61018 |
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