RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

RAS-like (RAL) GTPases function in Wnt signalling-dependent intestinal stem cell proliferation and regeneration. Whether RAL proteins work as canonical RAS effectors in the intestine and the mechanisms of how they contribute to tumourigenesis remain unclear. Here, we show that RAL GTPases are necess...

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Detalles Bibliográficos
Autores principales: Nászai, Máté, Bellec, Karen, Yu, Yachuan, Román-Fernández, Alvaro, Sandilands, Emma, Johansson, Joel, Campbell, Andrew D, Norman, Jim C, Sansom, Owen J, Bryant, David M, Cordero, Julia B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216719/
https://www.ncbi.nlm.nih.gov/pubmed/34096503
http://dx.doi.org/10.7554/eLife.63807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216719/
https://www.ncbi.nlm.nih.gov/pubmed/34096503
http://dx.doi.org/10.7554/eLife.63807

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