Molecular, Solid-State and Surface Structures of the Conformational Polymorphic Forms of Ritonavir in Relation to their Physicochemical Properties

PURPOSE: Application of multi-scale modelling workflows to characterise polymorphism in ritonavir with regard to its stability, bioavailability and processing. METHODS: Molecular conformation, polarizability and stability are examined using quantum mechanics (QM). Intermolecular synthons, hydrogen b...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Chang, Rosbottom, Ian, Turner, Thomas D., Laing, Sydney, Maloney, Andrew G. P., Sheikh, Ahmad Y., Docherty, Robert, Yin, Qiuxiang, Roberts, Kevin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217055/
https://www.ncbi.nlm.nih.gov/pubmed/34009625
http://dx.doi.org/10.1007/s11095-021-03048-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217055/
https://www.ncbi.nlm.nih.gov/pubmed/34009625
http://dx.doi.org/10.1007/s11095-021-03048-2

Ejemplares similares