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Molecular, Solid-State and Surface Structures of the Conformational Polymorphic Forms of Ritonavir in Relation to their Physicochemical Properties

PURPOSE: Application of multi-scale modelling workflows to characterise polymorphism in ritonavir with regard to its stability, bioavailability and processing. METHODS: Molecular conformation, polarizability and stability are examined using quantum mechanics (QM). Intermolecular synthons, hydrogen b...

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Detalles Bibliográficos
Autores principales:	Wang, Chang, Rosbottom, Ian, Turner, Thomas D., Laing, Sydney, Maloney, Andrew G. P., Sheikh, Ahmad Y., Docherty, Robert, Yin, Qiuxiang, Roberts, Kevin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217055/ https://www.ncbi.nlm.nih.gov/pubmed/34009625 http://dx.doi.org/10.1007/s11095-021-03048-2

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