Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization

Overexpression of the receptor tyrosine kinase HER2 plays a critical role in the development of various tumors. Biparatopic designed ankyrin repeat proteins (bipDARPins) potently induce apoptosis in HER2-addicted breast cancer cell lines. Here, we have investigated how the spatiotemporal receptor or...

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Detalles Bibliográficos
Autores principales: Stüber, Jakob C., Richter, Christian P., Bellón, Junel Sotolongo, Schwill, Martin, König, Iwo, Schuler, Benjamin, Piehler, Jacob, Plückthun, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217238/
https://www.ncbi.nlm.nih.gov/pubmed/34155320
http://dx.doi.org/10.1038/s42003-021-02253-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217238/
https://www.ncbi.nlm.nih.gov/pubmed/34155320
http://dx.doi.org/10.1038/s42003-021-02253-4

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