Modeling the mature CNS: A predictive screening platform for neurodegenerative disease drug discovery

BACKGROUND: Mature primary neuronal cultures are an important model of the nervous system, but limited scalability has been a major challenge in their use for drug discovery of neurodegenerative diseases. This work describes a method for improving scalability through the use of larger format microti...

Descripción completa

Detalles Bibliográficos
Autores principales: LaBarbera, Kelsie Mozzoni, Limegrover, Colleen, Rehak, Courtney, Yurko, Raymond, Izzo, Nicholas John, Knezovich, Nicole, Watto, Emily, Waybright, Lora, Catalano, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217273/
https://www.ncbi.nlm.nih.gov/pubmed/33836174
http://dx.doi.org/10.1016/j.jneumeth.2021.109180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217273/
https://www.ncbi.nlm.nih.gov/pubmed/33836174
http://dx.doi.org/10.1016/j.jneumeth.2021.109180

Ejemplares similares