First Sequencing of Caprine Mdr1 (Abcb1) mRNA Due to Suspected Neurological Adverse Drug Reaction in a Thuringian Goat Following Extra-Label Use of Doramectin

The multidrug resistance gene MDR1 encodes for an efflux transporter called P-glycoprotein (P-gp). In the canine Mdr1 gene, a nonsense mutation was identified in certain dog breeds causing increased drug sensitivity to various P-gp substrates such as antiparasitic macrocyclic lactones. Symptoms of n...

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Detalles Bibliográficos
Autores principales: Nürnberger, Daniela, Müller, Simon F., Hamann, Melanie, Geyer, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Veterinary Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217441/
https://www.ncbi.nlm.nih.gov/pubmed/34169111
http://dx.doi.org/10.3389/fvets.2021.682393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217441/
https://www.ncbi.nlm.nih.gov/pubmed/34169111
http://dx.doi.org/10.3389/fvets.2021.682393

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