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Vinaxanthone inhibits Semaphorin3A induced axonal growth cone collapse in embryonic neurons but fails to block its growth promoting effects on adult neurons

Semaphorin3A is considered a classical repellent molecule for developing neurons and a potent inhibitor of regeneration after nervous system trauma. Vinaxanthone and other Sema3A inhibitors are currently being tested as possible therapeutics to promote nervous system regeneration from injury. Our pr...

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Detalles Bibliográficos
Autores principales: Ivakhnitskaia, Evguenia, Chin, Matthew R., Siegel, Dionicio, Guaiquil, Victor H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217491/
https://www.ncbi.nlm.nih.gov/pubmed/34155284
http://dx.doi.org/10.1038/s41598-021-92375-w