A comprehensive analysis of novel disulfide bond introduction site into the constant domain of human Fab

Generally, intermolecular disulfide bond contribute to the conformational protein stability. To identify sites where intermolecular disulfide bond can be introduced into the Fab’s constant domain of the therapeutic IgG, Fab mutants were predicted using the MOE software, a molecular simulator, and ex...

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Detalles Bibliográficos
Autores principales: Nakamura, Hitomi, Yoshikawa, Moeka, Oda-Ueda, Naoko, Ueda, Tadashi, Ohkuri, Takatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217492/
https://www.ncbi.nlm.nih.gov/pubmed/34155225
http://dx.doi.org/10.1038/s41598-021-92225-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217492/
https://www.ncbi.nlm.nih.gov/pubmed/34155225
http://dx.doi.org/10.1038/s41598-021-92225-9

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