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Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly

Centrioles are evolutionarily conserved multi-protein organelles essential for forming cilia and centrosomes. Centriole biogenesis begins with self-assembly of SAS-6 proteins into 9-fold symmetrical ring polymers, which then stack into a cartwheel that scaffolds organelle formation. The importance o...

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Detalles Bibliográficos
Autores principales:	Hatzopoulos, Georgios N., Kükenshöner, Tim, Banterle, Niccolò, Favez, Tatiana, Flückiger, Isabelle, Hamel, Virginie, Andany, Santiago, Fantner, Georg E., Hantschel, Oliver, Gönczy, Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217511/ https://www.ncbi.nlm.nih.gov/pubmed/34155202 http://dx.doi.org/10.1038/s41467-021-23897-0

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