Multiplexed engineering glycosyltransferase genes in CHO cells via targeted integration for producing antibodies with diverse complex-type N-glycans

Therapeutic antibodies are decorated with complex-type N-glycans that significantly affect their biodistribution and bioactivity. The N-glycan structures on antibodies are incompletely processed in wild-type CHO cells due to their limited glycosylation capacity. To improve N-glycan processing, glyco...

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Detalles Bibliográficos
Autores principales: Nguyen, Ngan T. B., Lin, Jianer, Tay, Shi Jie, Mariati, Yeo, Jessna, Nguyen-Khuong, Terry, Yang, Yuansheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217518/
https://www.ncbi.nlm.nih.gov/pubmed/34155258
http://dx.doi.org/10.1038/s41598-021-92320-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217518/
https://www.ncbi.nlm.nih.gov/pubmed/34155258
http://dx.doi.org/10.1038/s41598-021-92320-x

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