Structural basis of the selective activation of enzyme isoforms: Allosteric response to activators of β1- and β2-containing AMPK complexes

AMP-activated protein kinase (AMPK) is a key energy sensor regulating the cell metabolism in response to energy supply and demand. The evolutionary adaptation of AMPK to different tissues is accomplished through the expression of distinct isoforms that can form up to 12 complexes, which exhibit nota...

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Detalles Bibliográficos
Autores principales: Aledavood, Elnaz, Forte, Alessia, Estarellas, Carolina, Javier Luque, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217686/
https://www.ncbi.nlm.nih.gov/pubmed/34194666
http://dx.doi.org/10.1016/j.csbj.2021.05.056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217686/
https://www.ncbi.nlm.nih.gov/pubmed/34194666
http://dx.doi.org/10.1016/j.csbj.2021.05.056

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