M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Rα2/MAPK Pathway in Rat Intervertebral Disc Degeneration

The accumulation of macrophages in degenerated discs is a common phenomenon. However, the roles and mechanisms of M2a macrophages in intervertebral disc degeneration (IDD) have not been illuminated. This study investigated the expression of the M2a macrophage marker (CD206) in human and rat interver...

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Detalles Bibliográficos
Autores principales: Li, Long, Wei, Kang, Ding, Yifan, Ahati, Paerxiati, Xu, Haoran, Fang, Huang, Wang, Huan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217759/
https://www.ncbi.nlm.nih.gov/pubmed/34168643
http://dx.doi.org/10.3389/fimmu.2021.666361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217759/
https://www.ncbi.nlm.nih.gov/pubmed/34168643
http://dx.doi.org/10.3389/fimmu.2021.666361

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