miR-27-3p Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to the Antitumor Agent Olaparib by Targeting PSEN-1, the Catalytic Subunit of Γ-Secretase

Olaparib has been used in the treatment of triple-negative breast cancer (TNBC) with BRCA mutations. In the present study, we demonstrated the effect of miR-27-3p on the γ-secretase pathway by regulating the sensitivity of TNBC cells to olaparib. miR-27-3p, a microRNA with the potential to target PS...

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Detalles Bibliográficos
Autores principales: Zhao, Meng, Sun, Baisheng, Wang, Yan, Qu, Gengbao, Yang, Hua, Wang, Pilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217819/
https://www.ncbi.nlm.nih.gov/pubmed/34169001
http://dx.doi.org/10.3389/fonc.2021.694491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217819/
https://www.ncbi.nlm.nih.gov/pubmed/34169001
http://dx.doi.org/10.3389/fonc.2021.694491

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