Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells

BACKGROUND: TET enzymes mediate DNA demethylation by oxidizing 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). Since these oxidized methylcytosines (oxi-mCs) are not recognized by the maintenance methyltransferase DNMT1, DNA dem...

Descripción completa

Detalles Bibliográficos
Autores principales: Onodera, Atsushi, González-Avalos, Edahí, Lio, Chan-Wang Jerry, Georges, Romain O., Bellacosa, Alfonso, Nakayama, Toshinori, Rao, Anjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218415/
https://www.ncbi.nlm.nih.gov/pubmed/34158086
http://dx.doi.org/10.1186/s13059-021-02384-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218415/
https://www.ncbi.nlm.nih.gov/pubmed/34158086
http://dx.doi.org/10.1186/s13059-021-02384-1

Ejemplares similares