Inhibitory affinity modulation of FcγRIIA ligand binding by glycosphingolipids by inside-out signaling

The interaction of the human FcγRIIA with immune complexes (ICs) promotes neutrophil activation and thus must be tightly controlled to avoid damage to healthy tissue. Here, we demonstrate that a fungal-derived soluble β-1,3/1,6-glucan binds to the glycosphingolipid long-chain lactosylceramide (LacCe...

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Detalles Bibliográficos
Autores principales: Okubo, Koshu, Brenner, Michael D., Cullere, Xavier, Saggu, Gurpanna, Patchen, Myra L., Bose, Nandita, Mihori, Saki, Yuan, Zhou, Lowell, Clifford A., Zhu, Cheng, Mayadas, Tanya N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218468/
https://www.ncbi.nlm.nih.gov/pubmed/34010642
http://dx.doi.org/10.1016/j.celrep.2021.109142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218468/
https://www.ncbi.nlm.nih.gov/pubmed/34010642
http://dx.doi.org/10.1016/j.celrep.2021.109142

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