Cargando…

Three-dimensional cultured mesenchymal stem cells enhance repair of ischemic stroke through inhibition of microglia

BACKGROUND: We show previously that three-dimensional (3D) spheroid cultured mesenchymal stem cells (MSCs) exhibit reduced cell size thus devoid of lung entrapment following intravenous (IV) infusion. In this study, we determined the therapeutic effect of 3D-cultured MSCs on ischemic stroke and inve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Yuejiao, Dong, Yankai, Ran, Ye, Zhang, Yanan, Wu, Boyao, Xie, Jundong, Cao, Yanpei, Mo, Miaohua, Li, Sen, Deng, Hao, Hao, Wenbo, Yu, Shengyuan, Wu, Yaojiong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218508/ https://www.ncbi.nlm.nih.gov/pubmed/34154653 http://dx.doi.org/10.1186/s13287-021-02416-4

Ejemplares similares

Mesenchymal stem cell aggregation mediated by integrin α4/VCAM-1 after intrathecal transplantation in MCAO rats
por: Ran, Ye, et al.
Publicado: (2022)

Engineered Skin Substitute Regenerates the Skin with Hair Follicle Formation
por: Wang, Jinmei, et al.
Publicado: (2021)

EGFR marks a subpopulation of dermal mesenchymal cells highly expressing IGF1 which enhances hair follicle regeneration
por: Chen, Min, et al.
Publicado: (2023)

Epigenetic changes of mesenchymal stem cells in three-dimensional (3D) spheroids
por: Guo, Ling, et al.
Publicado: (2014)

Modulatory effects of mesenchymal stem cells on microglia in ischemic stroke
por: Hao, Lei, et al.
Publicado: (2023)

Paracrine Molecules of Mesenchymal Stem Cells for Hematopoietic Stem Cell Niche
por: Li, Tian, et al.
Publicado: (2011)

PI3K/Akt signaling pathway is essential for de novo hair follicle regeneration
por: Chen, Yu, et al.
Publicado: (2020)

3D culture increases pluripotent gene expression in mesenchymal stem cells through relaxation of cytoskeleton tension
por: Zhou, Ying, et al.
Publicado: (2017)

Microglia polarization in ischemic stroke: complex mechanisms and therapeutic interventions
por: Mao, Jia-Hao, et al.
Publicado: (2021)

Platelet sonicates activate hair follicle stem cells and mediate enhanced hair follicle regeneration
por: Zhu, Meishu, et al.
Publicado: (2019)

Oleoylethanolamide Protects against Acute Ischemic Stroke by Promoting PPARα-Mediated Microglia/Macrophage M2 Polarization
por: Li, Ying, et al.
Publicado: (2023)

Modulators of microglia activation and polarization in ischemic stroke
por: Jiang, Cheng-Ting, et al.
Publicado: (2020)

Analysis of Allogenicity of Mesenchymal Stem Cells in Engraftment and Wound Healing in Mice
por: Chen, Liwen, et al.
Publicado: (2009)

Microglia autophagy in ischemic stroke: A double-edged sword
por: Peng, Li, et al.
Publicado: (2022)

A novel method for efficient delivery of stem cells to the ischemic brain
por: Guo, Ling, et al.
Publicado: (2013)

Depletion of Arg1-Positive Microglia/Macrophages Exacerbates Cerebral Ischemic Damage by Facilitating the Inflammatory Response
por: Li, Ting, et al.
Publicado: (2022)

Paracrine Factors of Mesenchymal Stem Cells Recruit Macrophages and Endothelial Lineage Cells and Enhance Wound Healing
por: Chen, Liwen, et al.
Publicado: (2008)

The Translational Potential of Microglia and Monocyte-Derived Macrophages in Ischemic Stroke
por: Wicks, Elizabeth E., et al.
Publicado: (2022)

Trichostatin A Stabilizes the Expression of Pluripotent Genes in Human Mesenchymal Stem Cells during Ex Vivo Expansion
por: Han, Bing, et al.
Publicado: (2013)

Sexually dimorphic microglia and ischemic stroke
por: Kerr, Nadine, et al.
Publicado: (2019)

The moderating effect of cognitive reserve on cognitive function in patients with Acute Ischemic Stroke
por: Li, Fanfan, et al.
Publicado: (2022)

Microglia and Their Promising Role in Ischemic Brain Injuries: An Update
por: Yu, Luting, et al.
Publicado: (2020)

Epigenetic Dysregulation in Mesenchymal Stem Cell Aging and Spontaneous Differentiation
por: Li, Zhilong, et al.
Publicado: (2011)

Dynamics of Microglia Activation in the Ischemic Brain: Implications for Myelin Repair and Functional Recovery
por: Raffaele, Stefano, et al.
Publicado: (2022)

Remote limb ischemic postconditioning inhibits microglia pyroptosis by modulating HGF after acute ischemia stroke
por: Yu, Lu, et al.
Publicado: (2023)

Cottonseed oil alleviates ischemic stroke injury by inhibiting the inflammatory activation of microglia and astrocyte
por: Liu, Min, et al.
Publicado: (2020)

Deletion of Angiotensin II Type 2 Receptor Accelerates Adipogenesis in Murine Mesenchymal Stem Cells via Wnt10b/beta-catenin Signaling
por: Matsushita, Kenichi, et al.
Publicado: (2016)

The Ischemic Environment Drives Microglia and Macrophage Function
por: Fumagalli, Stefano, et al.
Publicado: (2015)

Microglia: The Hub of Intercellular Communication in Ischemic Stroke
por: Zhang, Yunsha, et al.
Publicado: (2022)

Curcumin Protects against Ischemic Stroke by Titrating Microglia/Macrophage Polarization
por: Liu, Zongjian, et al.
Publicado: (2017)

M1 Microglia Induced Neuronal Injury on Ischemic Stroke via Mitochondrial Crosstalk between Microglia and Neurons
por: Liu, Wei, et al.
Publicado: (2022)

Engineering of human mesenchymal stem cells resistant to multiple natural killer subtypes
por: Zheng, Dejin, et al.
Publicado: (2022)

CD11c(+) microglia promote white matter repair after ischemic stroke
por: Jia, Junqiu, et al.
Publicado: (2023)

Treatment of ischemic stroke with modified mesenchymal stem cells
por: Chen, Hao, et al.
Publicado: (2022)

Neuroprotective Effects of Hesperetin in Regulating Microglia Polarization after Ischemic Stroke by Inhibiting TLR4/NF-κB Pathway
por: Zhang, Jiawen, et al.
Publicado: (2021)

Bone marrow mesenchymal stem cell exosomes-derived microRNA-216a-5p on locomotor performance, neuronal injury, and microglia inflammation in spinal cord injury
por: Xue, Hao, et al.
Publicado: (2023)

β-Catenin Signaling Evokes Hair Follicle Senescence by Accelerating the Differentiation of Hair Follicle Mesenchymal Progenitors
por: Han, Jimin, et al.
Publicado: (2022)

Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics
por: Fang, Shaoyi, et al.
Publicado: (2023)

Three-Dimensional Nanostructure of an Intact Microglia Cell
por: Bolasco, Giulia, et al.
Publicado: (2018)

Concise Review: Bone Marrow-Derived Stem/Progenitor Cells in Cutaneous Repair and Regeneration
por: Wu, Yaojiong, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ml556apu78eo7crmt7atp5ttsi