Synthesis of 1-indolyl-3,5,8-substituted γ-carbolines: one-pot solvent-free protocol and biological evaluation

1,5-Disubstituted indole-2-carboxaldehyde derivatives 1a–h and glycine alkyl esters 2a–c are shown to undergo a novel cascade imination-heterocylization in the presence of the organic base DIPEA to provide 1-indolyl-3,5,8-substituted γ-carbolines 3aa–ea in good yields. The γ-carbolines are fluoresce...

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Autores principales: Dudhe, Premansh, Krishnan, Mena Asha, Yadav, Kratika, Roy, Diptendu, Venkatasubbaiah, Krishnan, Pathak, Biswarup, Chelvam, Venkatesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218543/
https://www.ncbi.nlm.nih.gov/pubmed/34221174
http://dx.doi.org/10.3762/bjoc.17.101
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author Dudhe, Premansh
Krishnan, Mena Asha
Yadav, Kratika
Roy, Diptendu
Venkatasubbaiah, Krishnan
Pathak, Biswarup
Chelvam, Venkatesh
author_facet Dudhe, Premansh
Krishnan, Mena Asha
Yadav, Kratika
Roy, Diptendu
Venkatasubbaiah, Krishnan
Pathak, Biswarup
Chelvam, Venkatesh
author_sort Dudhe, Premansh
collection PubMed
description 1,5-Disubstituted indole-2-carboxaldehyde derivatives 1a–h and glycine alkyl esters 2a–c are shown to undergo a novel cascade imination-heterocylization in the presence of the organic base DIPEA to provide 1-indolyl-3,5,8-substituted γ-carbolines 3aa–ea in good yields. The γ-carbolines are fluorescent and exhibit anticancer activities against cervical, lung, breast, skin, and kidney cancer cells.
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spelling pubmed-82185432021-07-02 Synthesis of 1-indolyl-3,5,8-substituted γ-carbolines: one-pot solvent-free protocol and biological evaluation Dudhe, Premansh Krishnan, Mena Asha Yadav, Kratika Roy, Diptendu Venkatasubbaiah, Krishnan Pathak, Biswarup Chelvam, Venkatesh Beilstein J Org Chem Letter 1,5-Disubstituted indole-2-carboxaldehyde derivatives 1a–h and glycine alkyl esters 2a–c are shown to undergo a novel cascade imination-heterocylization in the presence of the organic base DIPEA to provide 1-indolyl-3,5,8-substituted γ-carbolines 3aa–ea in good yields. The γ-carbolines are fluorescent and exhibit anticancer activities against cervical, lung, breast, skin, and kidney cancer cells. Beilstein-Institut 2021-06-17 /pmc/articles/PMC8218543/ /pubmed/34221174 http://dx.doi.org/10.3762/bjoc.17.101 Text en Copyright © 2021, Dudhe et al. https://creativecommons.org/licenses/by/4.0/https://www.beilstein-journals.org/bjoc/terms/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). Please note that the reuse, redistribution and reproduction in particular requires that the author(s) and source are credited and that individual graphics may be subject to special legal provisions. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms/terms)
spellingShingle Letter
Dudhe, Premansh
Krishnan, Mena Asha
Yadav, Kratika
Roy, Diptendu
Venkatasubbaiah, Krishnan
Pathak, Biswarup
Chelvam, Venkatesh
Synthesis of 1-indolyl-3,5,8-substituted γ-carbolines: one-pot solvent-free protocol and biological evaluation
title Synthesis of 1-indolyl-3,5,8-substituted γ-carbolines: one-pot solvent-free protocol and biological evaluation
title_full Synthesis of 1-indolyl-3,5,8-substituted γ-carbolines: one-pot solvent-free protocol and biological evaluation
title_fullStr Synthesis of 1-indolyl-3,5,8-substituted γ-carbolines: one-pot solvent-free protocol and biological evaluation
title_full_unstemmed Synthesis of 1-indolyl-3,5,8-substituted γ-carbolines: one-pot solvent-free protocol and biological evaluation
title_short Synthesis of 1-indolyl-3,5,8-substituted γ-carbolines: one-pot solvent-free protocol and biological evaluation
title_sort synthesis of 1-indolyl-3,5,8-substituted γ-carbolines: one-pot solvent-free protocol and biological evaluation
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218543/
https://www.ncbi.nlm.nih.gov/pubmed/34221174
http://dx.doi.org/10.3762/bjoc.17.101
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