Randomized, Double-Blind, Placebo- and Positive-Controlled Crossover Study of the Effects of Tebipenem Pivoxil Hydrobromide on QT/QTc Intervals in Healthy Subjects

Tebipenem pivoxil hydrobromide (TBP-PI-HBr) is an orally available prodrug of tebipenem (TBP), a carbapenem with in vitro activity against multidrug-resistant Gram-negative pathogens. This study evaluated the effects of single therapeutic and supratherapeutic doses of TBP-PI-HBr on the heart rate-co...

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Detalles Bibliográficos
Autores principales: Gupta, Vipul K., Maier, Gary, Eckburg, Paul, Morelli, Lisa, Lei, Yang, Jain, Akash, Manyak, Erika, Melnick, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Clinical Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218669/
https://www.ncbi.nlm.nih.gov/pubmed/33875429
http://dx.doi.org/10.1128/AAC.00145-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218669/
https://www.ncbi.nlm.nih.gov/pubmed/33875429
http://dx.doi.org/10.1128/AAC.00145-21

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