Identification of a novel SPT inhibitor WXP-003 by docking-based virtual screening and investigation of its anti-fungi effect

Serine palmitoyltransferase (SPT) plays the key role on catalysing the formation of 3-ketodihydrosphingosine, which is the first step of the de novo biosynthesis of sphingolipids. SPT is linked to many diseases including fungal infection, making it a potential therapeutic target. Thus, a logical doc...

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Detalles Bibliográficos
Autores principales: Wang, Xin, Yang, Xin, Sun, Xin, Qian, Yi, Fan, Mengyao, Zhang, Zhehao, Deng, Kaiyuan, Lou, Zaixiang, Pei, Zejun, Zhu, Jingyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218698/
https://www.ncbi.nlm.nih.gov/pubmed/34148472
http://dx.doi.org/10.1080/14756366.2021.1915301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218698/
https://www.ncbi.nlm.nih.gov/pubmed/34148472
http://dx.doi.org/10.1080/14756366.2021.1915301

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