Rapid volunteer-based SARS-Cov-2 antibody screening among health care workers of a hospital in Mumbai, India

OBJECTIVES: COVID-19 is highly contagious, and health care workers are at high risk of being infected. We carried out a rapid survey to estimate the proportion of HCWs who are serologically positive for SARS-CoV-2 in the Lokmanya Tilak Municipal General Hospital, Mumbai, India. MATERIAL AND METHODS:...

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Autores principales: Baveja, Sujata, Karnik, Nitin, Natraj, Gita, Natkar, Milind, Bakshi, Asha, Krishnan, Anand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific Scholar 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219003/
http://dx.doi.org/10.25259/IJMS_234_2020
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author Baveja, Sujata
Karnik, Nitin
Natraj, Gita
Natkar, Milind
Bakshi, Asha
Krishnan, Anand
author_facet Baveja, Sujata
Karnik, Nitin
Natraj, Gita
Natkar, Milind
Bakshi, Asha
Krishnan, Anand
author_sort Baveja, Sujata
collection PubMed
description OBJECTIVES: COVID-19 is highly contagious, and health care workers are at high risk of being infected. We carried out a rapid survey to estimate the proportion of HCWs who are serologically positive for SARS-CoV-2 in the Lokmanya Tilak Municipal General Hospital, Mumbai, India. MATERIAL AND METHODS: After the consent of the hospital authorities, volunteers were asked to report at a special booth set up in the hospital between May 1, 2020, and May 16, 2020. After consent, each worker was administered a questionnaire using a handheld computer which had questions on symptoms in the past 30 days, place of posting (COVID designated area or other), work category (doctor/nurse/others), use of personal protective equipment, smoking, comorbidity, and exposure followed by a test for COVID-19 using the STANDARD Q COVID-19 IgM/ IgG Duo Test of SD Biosensor. We estimated weighted seroprevalence with 95% confidence limits after adjusting for the work category. We calculated the adjusted odds ratio (aOR) using logistic regression with seropositivity as an outcome variable and others as independent variables. RESULTS: The final sample included 501 and 1051 subjects working in the COVID area and non-COVID area, respectively, covering 35% of the total staff of the hospital. Overall, 6.9% (95% CI of 5.7–8.2) of the hospital staff was serologically positive for SARS-Cov-2, similar in the COVID area –5.7 (3.8–8.1) and non-COVID area –7.2 (5.7–9.0). Age more than 50 years (aOR 2.65; 1.45–4.85) and being in others work category 2.84 (1.34–6.02) were identified as significant predictors of being seropositive. Only 10% of the subjects reported COVID-like illness in the past 1 month. CONCLUSION: The overall modest prevalence of infection among the health care workers, especially non-doctors and nurses, and similarity of prevalence in COVID and non-COVID area staff indicate the possibility of non-hospital source of infection.
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spelling pubmed-82190032021-06-24 Rapid volunteer-based SARS-Cov-2 antibody screening among health care workers of a hospital in Mumbai, India Baveja, Sujata Karnik, Nitin Natraj, Gita Natkar, Milind Bakshi, Asha Krishnan, Anand Indian J Med Sci Original Article OBJECTIVES: COVID-19 is highly contagious, and health care workers are at high risk of being infected. We carried out a rapid survey to estimate the proportion of HCWs who are serologically positive for SARS-CoV-2 in the Lokmanya Tilak Municipal General Hospital, Mumbai, India. MATERIAL AND METHODS: After the consent of the hospital authorities, volunteers were asked to report at a special booth set up in the hospital between May 1, 2020, and May 16, 2020. After consent, each worker was administered a questionnaire using a handheld computer which had questions on symptoms in the past 30 days, place of posting (COVID designated area or other), work category (doctor/nurse/others), use of personal protective equipment, smoking, comorbidity, and exposure followed by a test for COVID-19 using the STANDARD Q COVID-19 IgM/ IgG Duo Test of SD Biosensor. We estimated weighted seroprevalence with 95% confidence limits after adjusting for the work category. We calculated the adjusted odds ratio (aOR) using logistic regression with seropositivity as an outcome variable and others as independent variables. RESULTS: The final sample included 501 and 1051 subjects working in the COVID area and non-COVID area, respectively, covering 35% of the total staff of the hospital. Overall, 6.9% (95% CI of 5.7–8.2) of the hospital staff was serologically positive for SARS-Cov-2, similar in the COVID area –5.7 (3.8–8.1) and non-COVID area –7.2 (5.7–9.0). Age more than 50 years (aOR 2.65; 1.45–4.85) and being in others work category 2.84 (1.34–6.02) were identified as significant predictors of being seropositive. Only 10% of the subjects reported COVID-like illness in the past 1 month. CONCLUSION: The overall modest prevalence of infection among the health care workers, especially non-doctors and nurses, and similarity of prevalence in COVID and non-COVID area staff indicate the possibility of non-hospital source of infection. Scientific Scholar 2020-12-31 /pmc/articles/PMC8219003/ http://dx.doi.org/10.25259/IJMS_234_2020 Text en © 2020 Published by Scientific Scholar on behalf of Indian Journal of Medical Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Baveja, Sujata
Karnik, Nitin
Natraj, Gita
Natkar, Milind
Bakshi, Asha
Krishnan, Anand
Rapid volunteer-based SARS-Cov-2 antibody screening among health care workers of a hospital in Mumbai, India
title Rapid volunteer-based SARS-Cov-2 antibody screening among health care workers of a hospital in Mumbai, India
title_full Rapid volunteer-based SARS-Cov-2 antibody screening among health care workers of a hospital in Mumbai, India
title_fullStr Rapid volunteer-based SARS-Cov-2 antibody screening among health care workers of a hospital in Mumbai, India
title_full_unstemmed Rapid volunteer-based SARS-Cov-2 antibody screening among health care workers of a hospital in Mumbai, India
title_short Rapid volunteer-based SARS-Cov-2 antibody screening among health care workers of a hospital in Mumbai, India
title_sort rapid volunteer-based sars-cov-2 antibody screening among health care workers of a hospital in mumbai, india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219003/
http://dx.doi.org/10.25259/IJMS_234_2020
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