Rapid volunteer-based SARS-Cov-2 antibody screening among health care workers of a hospital in Mumbai, India
OBJECTIVES: COVID-19 is highly contagious, and health care workers are at high risk of being infected. We carried out a rapid survey to estimate the proportion of HCWs who are serologically positive for SARS-CoV-2 in the Lokmanya Tilak Municipal General Hospital, Mumbai, India. MATERIAL AND METHODS:...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Scientific Scholar
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219003/ http://dx.doi.org/10.25259/IJMS_234_2020 |
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author | Baveja, Sujata Karnik, Nitin Natraj, Gita Natkar, Milind Bakshi, Asha Krishnan, Anand |
author_facet | Baveja, Sujata Karnik, Nitin Natraj, Gita Natkar, Milind Bakshi, Asha Krishnan, Anand |
author_sort | Baveja, Sujata |
collection | PubMed |
description | OBJECTIVES: COVID-19 is highly contagious, and health care workers are at high risk of being infected. We carried out a rapid survey to estimate the proportion of HCWs who are serologically positive for SARS-CoV-2 in the Lokmanya Tilak Municipal General Hospital, Mumbai, India. MATERIAL AND METHODS: After the consent of the hospital authorities, volunteers were asked to report at a special booth set up in the hospital between May 1, 2020, and May 16, 2020. After consent, each worker was administered a questionnaire using a handheld computer which had questions on symptoms in the past 30 days, place of posting (COVID designated area or other), work category (doctor/nurse/others), use of personal protective equipment, smoking, comorbidity, and exposure followed by a test for COVID-19 using the STANDARD Q COVID-19 IgM/ IgG Duo Test of SD Biosensor. We estimated weighted seroprevalence with 95% confidence limits after adjusting for the work category. We calculated the adjusted odds ratio (aOR) using logistic regression with seropositivity as an outcome variable and others as independent variables. RESULTS: The final sample included 501 and 1051 subjects working in the COVID area and non-COVID area, respectively, covering 35% of the total staff of the hospital. Overall, 6.9% (95% CI of 5.7–8.2) of the hospital staff was serologically positive for SARS-Cov-2, similar in the COVID area –5.7 (3.8–8.1) and non-COVID area –7.2 (5.7–9.0). Age more than 50 years (aOR 2.65; 1.45–4.85) and being in others work category 2.84 (1.34–6.02) were identified as significant predictors of being seropositive. Only 10% of the subjects reported COVID-like illness in the past 1 month. CONCLUSION: The overall modest prevalence of infection among the health care workers, especially non-doctors and nurses, and similarity of prevalence in COVID and non-COVID area staff indicate the possibility of non-hospital source of infection. |
format | Online Article Text |
id | pubmed-8219003 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Scientific Scholar |
record_format | MEDLINE/PubMed |
spelling | pubmed-82190032021-06-24 Rapid volunteer-based SARS-Cov-2 antibody screening among health care workers of a hospital in Mumbai, India Baveja, Sujata Karnik, Nitin Natraj, Gita Natkar, Milind Bakshi, Asha Krishnan, Anand Indian J Med Sci Original Article OBJECTIVES: COVID-19 is highly contagious, and health care workers are at high risk of being infected. We carried out a rapid survey to estimate the proportion of HCWs who are serologically positive for SARS-CoV-2 in the Lokmanya Tilak Municipal General Hospital, Mumbai, India. MATERIAL AND METHODS: After the consent of the hospital authorities, volunteers were asked to report at a special booth set up in the hospital between May 1, 2020, and May 16, 2020. After consent, each worker was administered a questionnaire using a handheld computer which had questions on symptoms in the past 30 days, place of posting (COVID designated area or other), work category (doctor/nurse/others), use of personal protective equipment, smoking, comorbidity, and exposure followed by a test for COVID-19 using the STANDARD Q COVID-19 IgM/ IgG Duo Test of SD Biosensor. We estimated weighted seroprevalence with 95% confidence limits after adjusting for the work category. We calculated the adjusted odds ratio (aOR) using logistic regression with seropositivity as an outcome variable and others as independent variables. RESULTS: The final sample included 501 and 1051 subjects working in the COVID area and non-COVID area, respectively, covering 35% of the total staff of the hospital. Overall, 6.9% (95% CI of 5.7–8.2) of the hospital staff was serologically positive for SARS-Cov-2, similar in the COVID area –5.7 (3.8–8.1) and non-COVID area –7.2 (5.7–9.0). Age more than 50 years (aOR 2.65; 1.45–4.85) and being in others work category 2.84 (1.34–6.02) were identified as significant predictors of being seropositive. Only 10% of the subjects reported COVID-like illness in the past 1 month. CONCLUSION: The overall modest prevalence of infection among the health care workers, especially non-doctors and nurses, and similarity of prevalence in COVID and non-COVID area staff indicate the possibility of non-hospital source of infection. Scientific Scholar 2020-12-31 /pmc/articles/PMC8219003/ http://dx.doi.org/10.25259/IJMS_234_2020 Text en © 2020 Published by Scientific Scholar on behalf of Indian Journal of Medical Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Baveja, Sujata Karnik, Nitin Natraj, Gita Natkar, Milind Bakshi, Asha Krishnan, Anand Rapid volunteer-based SARS-Cov-2 antibody screening among health care workers of a hospital in Mumbai, India |
title | Rapid volunteer-based SARS-Cov-2 antibody screening among health care workers of a hospital in Mumbai, India |
title_full | Rapid volunteer-based SARS-Cov-2 antibody screening among health care workers of a hospital in Mumbai, India |
title_fullStr | Rapid volunteer-based SARS-Cov-2 antibody screening among health care workers of a hospital in Mumbai, India |
title_full_unstemmed | Rapid volunteer-based SARS-Cov-2 antibody screening among health care workers of a hospital in Mumbai, India |
title_short | Rapid volunteer-based SARS-Cov-2 antibody screening among health care workers of a hospital in Mumbai, India |
title_sort | rapid volunteer-based sars-cov-2 antibody screening among health care workers of a hospital in mumbai, india |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219003/ http://dx.doi.org/10.25259/IJMS_234_2020 |
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