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Stepwise evolution and exceptional conservation of ORF1a/b overlap in coronaviruses
The programmed frameshift element (PFE) rerouting translation from ORF1a to ORF1b is essential for propagation of coronaviruses. A combination of genomic features that make up PFE—the overlap between the two reading frames, a slippery sequence, as well as an ensemble of complex secondary structure e...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219097/ https://www.ncbi.nlm.nih.gov/pubmed/34159333 http://dx.doi.org/10.1101/2021.06.14.448413 |