UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair

DNA-RNA hybrid structures have been detected at the vicinity of DNA double-strand breaks (DSBs) occurring within transcriptional active regions of the genome. The induction of DNA-RNA hybrids strongly affects the repair of these DSBs, but the nature of these structures and how they are formed remain...

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Detalles Bibliográficos
Autores principales: Ngo, Greg H. P., Grimstead, Julia W., Baird, Duncan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219777/
https://www.ncbi.nlm.nih.gov/pubmed/34158508
http://dx.doi.org/10.1038/s41467-021-24201-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219777/
https://www.ncbi.nlm.nih.gov/pubmed/34158508
http://dx.doi.org/10.1038/s41467-021-24201-w

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