The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling

MLKL phosphorylation by RIP3 is the commitment step of necroptosis execution, which could induce MLKL activation featured as MLKL monomer-oligomer transition. Here, we reported that the dimerization of the MLKL kinase-like domain was the direct consequence of RIP3 triggered MLKL-phosphorylation. Two...

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Detalles Bibliográficos
Autores principales: Zhang, Yu, Liu, Jia, Yu, Dandan, Zhu, Xinxin, Liu, Xiaoyan, Liao, Jun, Li, Sheng, Wang, Huayi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219780/
https://www.ncbi.nlm.nih.gov/pubmed/34158471
http://dx.doi.org/10.1038/s41419-021-03859-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219780/
https://www.ncbi.nlm.nih.gov/pubmed/34158471
http://dx.doi.org/10.1038/s41419-021-03859-6

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