Repurposing tRNAs for nonsense suppression

Three stop codons (UAA, UAG and UGA) terminate protein synthesis and are almost exclusively recognized by release factors. Here, we design de novo transfer RNAs (tRNAs) that efficiently decode UGA stop codons in Escherichia coli. The tRNA designs harness various functionally conserved aspects of sen...

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Detalles Bibliográficos
Autores principales: Albers, Suki, Beckert, Bertrand, Matthies, Marco C., Mandava, Chandra Sekhar, Schuster, Raphael, Seuring, Carolin, Riedner, Maria, Sanyal, Suparna, Torda, Andrew E., Wilson, Daniel N., Ignatova, Zoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219837/
https://www.ncbi.nlm.nih.gov/pubmed/34158503
http://dx.doi.org/10.1038/s41467-021-24076-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219837/
https://www.ncbi.nlm.nih.gov/pubmed/34158503
http://dx.doi.org/10.1038/s41467-021-24076-x

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