The molecular basis for the pH-dependent calcium affinity of the pattern recognition receptor langerin

The C-type lectin receptor langerin plays a vital role in the mammalian defense against invading pathogens. Langerin requires a Ca(2+) cofactor, the binding affinity of which is regulated by pH. Thus, Ca(2+) is bound when langerin is on the membrane but released when langerin and its pathogen substr...

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Detalles Bibliográficos
Autores principales: Joswig, Jan-O., Anders, Jennifer, Zhang, Hengxi, Rademacher, Christoph, Keller, Bettina G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219899/
https://www.ncbi.nlm.nih.gov/pubmed/33989634
http://dx.doi.org/10.1016/j.jbc.2021.100718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219899/
https://www.ncbi.nlm.nih.gov/pubmed/33989634
http://dx.doi.org/10.1016/j.jbc.2021.100718

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