p85β alters response to EGFR inhibitor in ovarian cancer through p38 MAPK-mediated regulation of DNA repair

EGFR signaling promotes ovarian cancer tumorigenesis, and high EGFR expression correlates with poor prognosis. However, EGFR inhibitors alone have demonstrated limited clinical benefit for ovarian cancer patients, owing partly to tumor resistance and the lack of predictive biomarkers. Cotargeting EG...

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Detalles Bibliográficos
Autores principales: Mak, Victor CY, Li, Xinran, Rao, Ling, Zhou, Yuan, Tsao, Sai-Wah, Cheung, Lydia WT
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220107/
https://www.ncbi.nlm.nih.gov/pubmed/34144267
http://dx.doi.org/10.1016/j.neo.2021.05.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220107/
https://www.ncbi.nlm.nih.gov/pubmed/34144267
http://dx.doi.org/10.1016/j.neo.2021.05.009

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